Ethyl trifluoroacetate (TFAE)

Ethyl trifluoroacetate

Alias: ethyl trifluoroacetate; Ethyl trifluoroacetate; Ethyl trifluoroacetate (TFAE); Ethyl trifluoroacetate

CAS No.: 383-63-1 Molecular formula: C4H5F3O2 Molecular weight: 142.08

EINECS：206-851-6 

Use and synthesis method of ethyl trifluoroacetate

brief introduction

Ethyl trifluoroacetate is a volatile, colorless and transparent liquid with the smell of ester. It is easily soluble in ether and ethanol, soluble in chloroform, slightly soluble in water, and can be slowly hydrolyzed in water. The vapor of ethyl trifluoroacetate can form an explosive mixture with air. It is extremely easy to burn and explode in case of open fire and high heat. It will decompose into highly toxic smoke in case of high heat, and react violently with oxidant

application

Ethyl trifluoroacetate (ETFA), as an important organic chemical raw material, has been widely used in the synthesis of organofluorine compounds, pharmaceuticals, pesticides, liquid crystals, dyes and other industries;

The specific applications are as follows: (1) In the field of medicine, it is mainly used in the production of anti-inflammatory drugs for osteoarthritis, colon drugs and anti-tumor drugs for straight Chemicalbook cancer, cardio-cerebrovascular drugs - Lenopril, etc;

(2) In terms of pesticides, it is mainly used to produce cell division inhibitors, which are used in cotton and peanut fields to remove gramineous weeds and broadleaf grasses;

(3) In organic synthesis, ethyl trifluoroacetate is often used for the protection of amino groups because of its low removal rate under mild conditions.

Colorless liquid with chemical properties. Boiling point 61.7 ℃, relative density 1.1953 (16/4 ℃), refractive index 1.3086, flash point - 1 ℃. Easily soluble in ethanol and ether, slightly soluble in water.

Use: for organic synthesis.

Use as medicine and pesticide intermediates Use as fine intermediates, widely used in the synthesis of fluorine-containing pesticides, pharmaceuticals and organic intermediates