BASIC INFORMATION:

Product Name: 1‑Bromo‑2,4‑dichlorobenzene

Chemical Formula: C₆H₃BrCl₂

Synonym: 2,4Dichlorobromobenzene

CAS: 1193-72-2

HS Code: 29039990

Molecular Weight: 225.90

Structural Formula: 214-778-6

Brief Description:

1Bromo2,4dichlorobenzene is a white to pale yellow crystalline powder. The unsymmetrical substitution pattern provides regioselectivity in coupling reactions, making it an important chemical intermediate.

TECHNICAL INDICATORS:

APPLICATIONS:

1. Pharmaceutical intermediate: Used in the synthesis of antimalarial drugs (e.g., chloroquine halogenated derivatives) and anti‑inflammatory agents (e.g., bromine‑containing precursors of diclofenac). Example: conversion of bromine to cyano, followed by hydrolysis to 2,4‑dichlorobenzoic acid, then preparation of amide‑type analgesics.

2. Pesticide intermediate: Used for triazole alcool fungicides (e.g., halogenated benzene ring of tebuconazole) and acaricides (e.g., analogues of pyridaben).

3. Dyes and pigments: Used as a halogenated aromatic component in phthalocyanine blue and green pigments to adjust shade and fastness.

4. Polymer additives: As an intermediate for brominated flame retardants, used in the preparation of low‑oligomeric brominated diphenyl ethers.

STORAGE CONDITIONS:

1. Store in a cool, dry, well‑ventilated area.

2. Keep container tightly sealed; store under inert gas, avoid moisture.

3. Separate from oxidizing agents – do not mix storage.

4. Ventilation systems should be equipped with static electricity grounding.

5. The storage area should be equipped with spill containment and appropriate collection materials.

PACKAGE:

1. Tightly sealed container.

2. Other packaging forms available upon request.

CHEMICAL PROPERTIES:

Melting point: 26–30°C (may partially liquefy at room temperature), boiling point: 235°C, flash point: >110°C. The bromine atom is ortho to one chlorine and para to the other, making it susceptible to metalation. Low vapor pressure (0.07 mmHg) indicates low volatility. Skin irritant; wear protective gloves when handling.