BASIC INFORMATION:

Product Name: m-Fluoroanisole

Chemical Formula: C₇H₇FO

Synonyms: 3-Fluoroanisole, m-Fluoromethoxybenzene, 1-Fluoro-3-methoxybenzene

CAS: 456-49-5

HS Code: 29093090

Molecular Weight: 126.13

Einecs: 207-267-4

Structural Formula:

Brief Description:

m-Fluoroanisole (also known as 3-fluoroanisole) is an important fluorinecontaining aromatic ether organic intermediate. At room temperature, it is a pale yellow liquid, flammable, and potentially hazardous to aquatic environments. It is mainly used as an intermediate in pesticides and pharmaceuticals. It can be synthesized from 3-fluorophenol and methanol.

TECHNICAL INDICATORS:

APPLICATIONS:

1. Pharmaceutical intermediate: Used in the synthesis of antipsychotic drugs such as risperidone and its derivatives; also used as a side‑chain intermediate for fluconazole‑type antifungals. Example: conversion to 3‑fluoro‑4‑methoxyaniline for further preparation of antidepressant drugs.

2. Pesticide intermediate: Used to prepare fluorine‑containing diphenyl ether herbicides, e.g., analogues of acifluorfen, and as an aromatic ring modification intermediate for insecticides such as fipronil.

3. Organic functional materials: Used as a monomer for synthesizing fluorine‑containing liquid crystal display materials, improving dielectric anisotropy and response speed. Also used to prepare bridging ligands for metal‑organic frameworks.

STORAGE CONDITIONS:

1. Store in a cool, dry, well‑ventilated area away from ignition sources and heat.

2. Keep container tightly sealed; store under inert gas or in a dry environment to avoid moisture.

3. Separate from oxidizing agents and food chemicals – do not mix storage.

4. Ventilation systems should be equipped with static electricity grounding.

5. The storage area should be equipped with spill containment and appropriate collection materials.

PACKAGE:

1. Polyethylene plastic drums or steel‑plastic composite drums, with moisture‑proof inner liner.

2. Other packaging forms available upon request.

CHEMICAL PROPERTIES:

Boiling point: 158°C (743 mmHg), flash point: 111°F (~44°C), refractive index: 1.488. The fluorine atom reduces the electron density of the benzene ring; the methoxy group is ortho/paradirecting. Can undergo FriedelCrafts reactions in the presence of Lewis acids. Freely soluble in ethanol, ether and other organic solvents; insoluble in water. Flammable liquid; store away from ignition sources.